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- Rate of excretion of secretory immunoglobulin A in human is enhanced by 4-week intake of chlorella
Rate of excretion of secretory immunoglobulin A in human is enhanced by 4-week intake of chlorella
【Scientific information】
Research and Development Department, Sun Chlorella Corporation
Rate of excretion of secretory immunoglobulin A in human is enhanced by 4-week intake of chlorella
Presented at the 9th Annual Meeting of the Japanese Society of Anti-Aging Medicine (2009)
- Study Objectives
- Secretory immunoglobulin A (SIgA) contained in saliva plays an important role in mucosal defense in the throat against invasion of pathogenic agents responsible for colds and influenza and other foreign substances. We performed a clinical trial to investigate the effects of chlorella intake on secretion of SIgA in saliva, since studies have reported enhanced immune function in rats and increases in IgA concentration in mother's milk following ingestion of chlorella.
- Method and experiments
- A blind crossover trial was performed in 21 healthy men. The subjects received tablets of chlorella or placebo grains twice daily (15 tablets at a time, 30 tablets per day) for 4 weeks, and saliva samples were obtained from the subjects before and after treatment. Saliva samples were obtained with sterile cotton swabs chewed at a rate of once per second for 2 minutes. Rate of saliva secretion and SIgA concentration were measured for the samples obtained, and the SIgA secretion rate was calculated. The t-test was performed for comparison of findings obtained in the placebo (P group) and chlorella groups (C group) before and after treatment.
- Results
- The rate of intake of the test substances was 97.0 1.0% in the P group and 95.2 1.4% in the
C group, and not significantly different between groups. Although there was no significant change
in SIgA concentration before to after treatment in the P group (p = 0.19), in the C group there was
a significant increase in this parameter after treatment (p < 0.01). There were no significant
differences in saliva secretion rate before to after treatment in either group (p = 0.23 and p = 0.73
for the P and C groups, respectively). Although the SIgA secretion rate after treatment did not
change significantly from that before treatment in the P group (p = 0.32), it was significantly
increased after treatment in the C group (p = 0.01).
These findings suggested that SIgA concentration and rate of secretion in saliva were increased and immune function in the oral cavity was improved after 4-week treatment with chlorella.
Presentation at a scientific meeting
- Name of meeting：
- The 9th Annual Meeting of the Japanese Society of Anti-Aging Medicine, 2009
- Title：
- Rate of excretion of secretory immunoglobulin A in human is enhanced by 4-week intake of chlorella
- Presenters：
- Takeshi Otsuki,1) Kazuhiro Shimizu2), Motoyuki Iemitsu3), Yukari Arakawa4), and Ichiro Kohno2)
- Affiliation：
- 1) St. Catherine University, Department of Health and Social Welfare Management, 2) University of Tsukuba Graduate School, Department of Comprehensive Human Sciences, 3) International Pacific University, Department of Physical Education, 4) Sun Chlorella Corporation
This leaflet reproduces presentations made in scientific journals or meetings and is not intended for sales or promotion of any product.
